Signalling ballet in four dimensions: analogue-to-digital conversions control the cell fate

The advancements in “omics” (proteomics, genomics, and metabolomics) technologies have yielded large inventories of genes, transcripts, proteins, and metabolites. The challenge is to find out how these entities work together to regulate cellular responses to external and internal cues. Computational models provide insight into the intricate relationships between stimuli and responses, revealing mechanisms that enable networks to amplify signals and reduce noise and generate discontinuous bistable dynamics or oscillations. In this talk, we review experimental and theoretical progress towards better understanding how the cellular functions are encoded by the spatiotemporal dynamics of downstream signalling networks. We focus on how cellular networks integrate the temporal and spatial information to determine specific biological outcomes, and how the design features of the networks specify biological decisions.

@InProceedings{Kho13,
  author       = {Kholodenko, B.},
  title        = {Signalling ballet in four dimensions: analogue-to-digital conversions control the cell fate},
  booktitle    = {Collana Talks@CRS4},
  number       = {20130215},
  month        = {february},
  year         = {2013},
  note         = {seminar delivered at CRS4 on Feb 15, 2013 - contact: Vladimir Zimont, zimont@crs4.it},
  keywords     = {Systems Biology, Cell Communication, Cell Lineage, Humans, Signal Transduction, Time Factors, Transcription, Genetic},
  url          = {https://publications.crs4.it/pubdocs/2013/Kho13},
}