Simulation based understanding towards Structural and Biochemical Perspectives of Calsequestrin

Calsequestrin is the major calcium binding protein present in the sarcoplasmic reticulum of striated muscles, is responsible for buffering calcium during excitation-contraction coupling. It is present in two isoforms the skeletal and cardiac, but none of its structure and thereby its mode of action is completely understood. From our studies we tried to find out the critical residues participating in the polymerization of the protein and how its mutations affect its function. Further describing the biochemical function we suggested its Ca2+ selectivity, which was proven biologically. Finally we also studied the protein in its dimeric from to understand the role of the missing C-terminal in the skeletal isoform and identified the important Ca2+ binding residues. Overall our studies describes the structural and biochemical functions of Calsequestrin.

@InProceedings{Cha14,
  author       = {Chakravarty, H.},
  title        = {Simulation based understanding towards Structural and Biochemical Perspectives of Calsequestrin},
  booktitle    = {Collana Talks@CRS4},
  number       = {20140513},
  month        = {may},
  year         = {2014},
  note         = {seminar delivered at CRS4 on May 13, 2014 - contact: Enrico Pieroni, ep@crs4.it},
  keywords     = {Computational Chemistry, Calcium Binding, Calcium Signalling, Calsequestrin, Muscle Contraction},
  url          = {https://publications.crs4.it/pubdocs/2014/Cha14},
}